Analysis of MDR-TB Treatment Management and ADR in Our Hospital
10.6039/j.issn.1001-0408.2017.32.07
- VernacularTitle:我院耐多药结核病治疗管理及药品不良反应发生情况分析
- Author:
Debing DU
1
Author Information
1. 宜昌市第三人民医院结核科
- Keywords:
MDR-TB;
Treatment management;
ADR;
Clinical analysis
- From:
China Pharmacy
2017;28(32):4492-4495
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for rational use of antituberculosis drugs and reduce the occurrence of ADR in multiple-drug resistance tuberculosis (MDR-TB) patients.METHODS:TB inpatients were selected from our hospital during Feb.2012-May 2015,and then divided into suspected MDR-TB group (202 cases) and diagnosed MDR-TB group (162 cases).According to the patient's condition,different treatment management modes were chosen,and the incidence of ADR were observed.Treatment and management period of 2 groups were 18 months.RESULTS:In suspected MDR-TB group,the drug resistance rates to first line drugs were greater than or equal to 26.24%,among which drug resistance rates to isoniazid and rifampicin were about 40%.Resistance rates to second line-drugs were greater than or equal to 4.95%,among which resistance rate to protionamide was the highest,being 46.04%.The results of drug sensitivity tests showed that 44.06% of patients were sensitive to all first-line drugs,14.36% of patients were resistant to single drug,9.90% of patients were usually resistant to drugs and 31.68% of patients were resistant to multiple drugs.21.78% of patients were sensitive to all first-line drugs and second-line drugs,24.75% of patients were resistant to single drug,17.82% of patients were usually resistant to drugs,32.67% of patients were resistant to multiple drugs and 2.97% of patients were extensively resistant to drugs.In the management plan of MDR-TB patients therapy,56.17% were treated in tuberculosis control institutions;referral to special hospital for treatment accounted for 14.81%;22.22% didn't receive any treatment;other factors lead to a change in treatment or unable to continue to treat accounted for 6.79%.The incidence of ADR in MDR-TB patients was higher than suspected MDR-TB patients,there was statistical significance between 2 groups (P<0.05).After the following symptomatic treatment,all patients were improved.CONCLUSIONS:For patients with MDR-TB,according to disease condition,appropriate treatment management program can be found so as to improve therapeutic efficacy,reduce the incidence of ADR,control spreading and development of tubercle bacillus.