Analysis of the Rationality of Perioperative PPIs in the Prevention of Stress Ulcer in Orthopedic Department of Our Hospital
10.6039/j.issn.1001-0408.2017.32.05
- VernacularTitle:我院骨科患者围术期质子泵抑制剂预防应激性溃疡的合理性分析
- Author:
Jianjie CHU
1
;
Tingting FAN
;
Minna YAO
;
Yanhua WANG
;
Zeqiong NING
;
Mingming WANG
;
Wei ZHANG
;
Weiwei LI
;
Aidong WEN
Author Information
1. 第四军医大学第一附属医院药剂科
- Keywords:
Proton pump inhibitors;
Stress ulcer;
Perioperative;
Rational drug use
- From:
China Pharmacy
2017;28(32):4483-4487
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the rationality of proton pump inhibitors (PPIs) in the prevention of stress ulcer in perioperative orthopedic patients of our hospitals,and to provide reference for ratioual use of PPIs in clinic.METHODS:The medical records of discharged orthopedic patients were selected during Jan.1st-30th in 2016.Those records were analyzed statistically in respects of the use of PPIs,general information of patients,operation situation,the stressors and risk factors of stress ulcer.The rationality of the use of PPIs was analyzed comprehensively.RESULTS:Among 664 surgical patients,PPIs were used in 210 cases,and H2 receptor antagonist (H2RA) were used in 74 cases,with prophylactic rate of 42.77％.The main types of operation were fracture fixation (74 cases,35.24％),discectomy and discectomy (38 cases,18.11％).Among 210 patients receiving PPIs,all of them used PPIs,among which 68 cases (32.38％) had no medication indications,128 cases (60.95％) were medication timing error,74 cases (35.24％) were administration frequency error and 44 cases (20.95％) were more than 3 d prophylactic drug use.CONCLUSION:When orthopedic patients use PPIs for the prevention of stress ulcer,there are serious irrational phenomena in indications,species selection,usage and dosage,treatment course and so on.Clinicians and regulators should pay great attention to it so as to avoid the excessive application of PPIs.
