Rolapitant Combined with 5-HT3 Receptor Antagonist and Dexamethasone for the Prevention and Treatment of Chemotherapy-induced Nausea and Vomiting: A Systematic Review
10.6039/j.issn.1001-0408.2017.30.18
- VernacularTitle:罗拉吡坦联合5-羟色胺3受体拮抗药和地塞米松防治化疗相关性恶心呕吐的系统评价
- Author:
Kun CHEN
1
;
Ting HUANG
;
Hongli LUO
;
Yun YE
Author Information
1. 西南医科大学附属医院药学部
- Keywords:
Rolapitant;
Chemotherapy-induced nausea and vomiting;
Systematic review;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(30):4242-4247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effectiveness and safety of rolapitant combined with 5-HT3 receptor antagonist and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting systematically,and to provide evidence-based reference in clinic.METHODS:Retrieved from CJFD,VIP,Wanfang Database,PubMed,EMBase and Cochrane Library,randomized controlled trials (RCTs) about rolapitant+5-HT3 receptor antagonist+ dexamethasone (trial group) vs.placebo combined with 5-HT3 receptor antagonist+dexamethasone (control group) for the prevention of chemotherapy-induced nausea and vomiting.Meta-analysis was performed by using Rev Man 5.3 statistical software after data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0.RESULTS:A total of 3 literatures were included,involving 4 RCTs and 2 583 patients.The results of Meta-analysis were as follows:complete remission rate [acute stage:RR=1.10,95％ CI (1.02,1.19),P=0.01;delay stage:RR=1.18,95％ CI (1.11,1.25),P＜0.001;overall stage:RR=1.19,95 ％ CI (1.12,1.26),P＜0.001] and the proportion of patients with ftmctional indexes of vomiting living ＞ 108 [RR =1.10,95 ％ CI (1.04,1.16),P ＜ 0.001] in trial group were significantly higher than control group,with statistical significance.There was no statistical significance in the incidence of ADR between 2 groups[RR=1.10,95 ％ CI (0.82,1.47),P=0.52].CONCLUSIONS:Rolapitant combined with 5-HT3 receptor antagonist and dexamethasone can effectively prevent and relieve chemotherapy-induced nausea and vomiting,and improve the quality of life with good safety.
