Meta-analysis of Therapeutic Efficacy and Safety of Valaciclovir versus Acyclovir in the Treatment of Herpes Zoster
10.6039/j.issn.1001-0408.2017.30.17
- VernacularTitle:伐昔洛韦对比阿昔洛韦治疗带状疱疹疗效和安全性的Meta分析
- Author:
Li WANG
1
;
Tingting WEN
;
Xiuping JI
;
Chengyu MA
;
Zhuo FAN
Author Information
1. 西安医学院第一附属医院
- Keywords:
Valaciclovir;
Acyclovir;
Herpes zoster;
Meta-analysis;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2017;28(30):4238-4241
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate therapeutic efficacy and safety of valaciclovir versus acyclovir in the treatment of herpes zoster,and to provide evidence-based reference in clinic.METHODS:Retrieved from PubMed,Medline,CJFD,VIP and Wanfang Database,randomized controlled trials (RCTs) about valaciclovir (trial group) versus acyclovir (control group) in the treatment of herpes zoster were included.The data was analyzed statistically by using Rev Man 5.3 software after data extraction and quality evaluation by Cochrane systematic reviewer manual 5.1.0.RESULTS:A total of 12 RCTs were included,involving 1 059 patients.The result of Meta-analysis showed that:total response rate [OR =4.64,95 ％ CI (2.99,7.20),P＜ 0.001] and cure rate [OR =2.93,95％CI(2.13,4.03),P＜0.001] of trial group were significantly higher than those of control group;the incidence of postherpetic neuralgia in trial group [OR=0.39,95％CI(0.22,0.69),P=0.001] was significantly lower than control group,with statistical significance.There was no statistical significance in the incidence of ADR between 2 groups [OR=0.79,95％CI(0.49,1.29),P=0.35].CONCLUSIONS:Therapeutic efficacy of valaciclovir is better than that of acyclovir in the treatment of herpes zoster,can significantly reduce the incidence of postherpetic neuralgia.Both have similar safety.
