Effects of Plasma Exchange Combined with Intensive Insulin Glycemic Control on Related Indexes of Patients with Hyperlipidemic Pancreatitis
10.6039/j.issn.1001-0408.2017.30.07
- VernacularTitle:血浆置换联合胰岛素强化降糖对高脂血症性胰腺炎患者相关指标的影响
- Author:
Wenbin TIAN
1
;
Kang JIN
;
Ruiqi CAO
;
Xueqing LI
;
Ruopeng CHU
Author Information
1. 河北医科大学第二医院麻醉ICU
- Keywords:
Hyperlipidemic pancreatitis;
Plasma exchange;
Insulin;
Intensive glycemic control;
Triglyceride;
Inflammatory reaction;
Prognosis
- From:
China Pharmacy
2017;28(30):4202-4205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of plasma exchange (PE) combined with intensive insulin glycemic control on related indexes of patients with HLP.METHODS:A total of 120 HLP patients were randomly divided into control group (60 cases) and observation group (60 cases).Based on routine treatment,2 groups were given PE treatment for 3 times+Low molecular weight heparin calcium for injection 5 000 U subcutaneously+Methylprednisolone sodium succinate for injection 40 mg intravenously+Calcium gluconate injection 2 g intravenously.Based on it,Insulin injection was pumped to random blood glucose ＜12 mmol/L with a micro-infusion pump in control group when random blood glucose concentration was equal to or more than 12 mmol/ L.When random blood glucose of patients in observation group were higher than 8.3 mmol/L,Insulin injection was pumped with a micro-infusion pump for a week and random blood glucose concentration was maintained at 6.1-8.3 mmol/L.Plasma levels of triglyceride,PCT,WBC count,APACHE Ⅱ score,Balthazar CT score,length of hospitalization stay in ICU and the occurrence of ADR were observed in 2 groups before and after treatment.RESULTS:After treatment,plasma levels of triglyceride,amylase and PCT,WBC count,APACHE Ⅱ score and Balthazar CT score in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistical significance(P＜0.05).Length of hospitalization stay in ICU observation group was significantly shorter than control group,with statistical significance(P＜0.05).There was no statistical significance in the incidence of ADR between 2 groups(P＞0.05).CONCLUSIONS:PE combined with intensive insulin glycemic control can effectively reduce the level of plasma triglyceride,relieve inflammatory reaction and improve prognosis without increasing the occurrence of ADR.
