Effects of Aerobic Exercise on Plasma Metabolites in Prediabetes Subjects
- VernacularTitle:有氧运动对糖尿病前期人群血浆代谢物的影响
- Author:
Bowen LI
1
;
Mian JIA
;
Ningning ZHANG
;
Chaojun LI
;
Yan WANG
;
Xianbo ZHANG
;
Yu ZHOU
;
Zhengzhen WANG
Author Information
1. 北京体育大学运动医学与康复学院
- Keywords:
pre-diabetes mellitus;
aerobic exercise;
metabonomics;
phospholipid;
LC-MS
- From:
Chinese Journal of Sports Medicine
2018;37(4):301-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of aerobic exercise training on plasma metabolites in pre-diabetes mellitus(PDM)subjects.Methods Twenty-five PDM subjects were selected,and each 10 age-and sex-matched with normoglycemia and new-onset T2DM subjects were enrolled.PDM subjects underwent aerobic exercise(n=13)or health education (n=12) for 12 weeks.The aerobic exercise was con ducted 3 times/week,50 min/time at 40％-60％ of oxygen uptake reserve.Liquid chromatography-mass spectrometry(LC-MS)was used to analyze the spectrum of plasma metabolites.Principal component analysis was employed to study the differences in plasma metabolite profiles between subjects with different glycemic level and between PDM subjects before and after aerobic exercise.Results After training,the body fat percentage,2-hour plasma glucose,and low density lipoprotein cholesterol of PDM subjects reduced significantly(by 4.6％,16.22％ and 9.27％ on average).Comparison of plasma metabolizers in PDM subjects before and after exercise revealed 31 differential metabolites,with 25 metabolites such as phosphatidylcholine,lysophosphatidylcholines,sphingomyelin and betaine increasing,and 6 metabolites,such as oleic acid and cytosine decreasing.Conclusion Aerobic exercise has a marked effect on the plasma metabolites in PDM subjects.Phosphatidylcholine,lysophosphatidylcholines,sphingomyelin and oleic acid may be the potential biomarkers of aerobic exercise improving the glycolipid metabolism in PDM subjects.These findings can help us better understand the mechanism of aerobic exercise preventing T2DM diabetes.
