Advances of active ingredients of traditional Chinese medicine in the preven-tion and treatment of osteoarthritis
10.11665/j.issn.1000-5048.20180304
- VernacularTitle:中药有效成分防治骨性关节炎的研究进展
- Author:
Han HAN
1
;
Yuanyuan ZHANG
;
Li PAN
;
Zhengdong CHEN
;
Lixuan XUE
;
Boyang YU
;
Jun-Ping KOU
Author Information
1. 中国药科大学江苏省中药评价与转化重点实验室
- Keywords:
traditional Chinese medicine;
active ingredients;
osteoarthritis;
mechanism
- From:
Journal of China Pharmaceutical University
2018;49(3):279-285
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA),a common chronic degenerative joint disease,rises gradually with age,which seri-ously affects the quality of life of middle-aged and elderly patients. Currently,the therapeutic medications such as nonsteroidal anti-inflammatory drugs (NSAIDs)and analgesics might improve OA symptoms,but cannot prevent the development of OA. The active ingredients of traditional Chinese medicine (TCM)have unique advantages in the treatment of OA. This article reviews the research progress of active ingredients of TCM in the prevention and treatment of OA reported by domestic and foreign journals in the past five years from the aspects of inhibition of the secretion of inflammation-related factors,improvement of cartilage matrix synthesis and catabolic imbalance, inhibition of chondrocyte apoptosis,promotion of chondrocyte proliferation,and regulation of estrogen levels,with an attempt to provide a theoretical basis for the development of new drugs for OA.
