Advances in the hypoxia-responsive antitumor drug nanocarriers and tumor hypoxia relieve
10.11665/j.issn.1000-5048.20180301
- VernacularTitle:改善肿瘤乏氧环境及乏氧应激释药型抗肿瘤药纳米递送系统研究进展
- Author:
Jinlai LIANG
1
;
Wei XU
;
Tingjie YIN
;
Meirong HUO
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室
- Keywords:
hypoxia;
oxygen delivery;
H2O2;
hypoxia environment;
hypoxia-responsive;
nanocarriers;
antitumor
- From:
Journal of China Pharmaceutical University
2018;49(3):255-262
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia,a salient feature of solid tumors,is often associated with invasiveness,metastasis and resistance to anticancer drugs.The strategies including the use of oxygen-carriers based on hyperbaric oxygen and blood substitutes to transport oxygen into tumors or in situ generation of O2from the tumor microenvironment endogenous H2O2have been explored to relieve the tumor hypoxia and to improve therapeutic efficiency.In addi-tion,it is potential to design hypoxia-responsive nanocarriers based on tumor hypoxia microenvironment to deliver anticancer drugs to the targeted tumor site,thereby improve drug concentrations in targeted site,significantly increase the antitumor efficiency and reduce the side-effects of drugs.This review gives an overview of the advances in relieving tumor hypoxia and hypoxia-responsive nanocarriers for tumor to provide a reference for the research and development of new antitumor drugs.
