Synthesis and cytotoxicity study of cembrane triazole derivatives
10.11665/j.issn.1000 -5048.20180108
- VernacularTitle:西松烷型二萜三氮唑衍生物的合成及其细胞毒活性
- Author:
Weihua CHENG
1
;
Wenqian WANG
;
Hai SHANG
;
Hongwu ZHANG
;
Qiang GUO
;
Hong CHEN
;
Zhongmei ZOU
Author Information
1. 中国医学科学院北京协和医学院药用植物研究所
- Keywords:
cembrane;
triazole;
synthesis;
structural modification;
cytotoxicity;
anti-drug-resistance activity
- From:
Journal of China Pharmaceutical University
2018;49(1):56-63
- CountryChina
- Language:Chinese
-
Abstract:
A series of triazole derivatives were designed and synthesized based on a natural product cembrane separated from Croton laevigatus Vahl which showed potential antitumor activity against HeLa cells.Twelve novel compounds were synthesized and their structures were characterized by 1H NMR, 13C NMR and HRMS.Their cytotoxicities in vitro were evaluated for HeLa,K562 and K562/A02 cells by MTT assay.The results showed that some cembrane derivatives possessed antitumor activities.Substituted triazole connected to cembrane derivatives exhibited potent activity toward drug-resistant K562/A02 cells.
