Advances in the targeted therapy of tumor-associated fibroblasts
10.11665/j.issn.1000 -5048.20180103
- VernacularTitle:靶向肿瘤相关成纤维细胞治疗策略的研究进展
- Author:
Han CAI
1
;
Yanhong LIU
;
Tingjie YIN
;
Jianping ZHOU
;
Meirong HUO
Author Information
1. 中国药科大学天然药物活性组分与药效国家重点实验室
- Keywords:
tumor microenvironment;
tumor-associated fibroblasts;
enzyme-activated prodrugs;
nanoparticles;
TAFs targeted therapy
- From:
Journal of China Pharmaceutical University
2018;49(1):20-25
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated fibroblasts(TAFs),the most important stromal cells of the tumor microenvironment (TME),have been found to support tumorigenesis and tumor metastasis in a variety of ways,including paracrine, direct contact with cells,immune regulation and extracellular matrix remolding.Therefore,TAFs in the TME have been an optimal target for cancer therapy.In this review,the TAFs targeted therapies are summarized to provide the new strategy for tumor treatments based on the analysis of the location and specific biological phenotypes of TAFs in tumors.
