Research advances of multi-targeted flavonoids in the intervention of Alzhei-mer's disease
10.11665/j.issn.1000 -5048.20180102
- VernacularTitle:具有多靶点抗阿尔茨海默病活性的黄酮类化合物研究进展
- Author:
Lijuan YUAN
1
;
Keren WANG
;
Zhipei SANG
Author Information
1. 杭州市余杭区第一人民医院药剂科
- Keywords:
Alzheimer′s disease;
multi-target directed ligands;
flavonoids
- From:
Journal of China Pharmaceutical University
2018;49(1):10-19
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease(AD)is a chronic progressive neurodegenerative disease in the elderly,which causes heavy burden for the society and family.The current drugs could only improve the cognitive symptoms in the short term,but could not reverse or stop the disease progression.In view of the complexity of AD,multi-targe-ted drugs could be a potential strategy for the treatment of AD.Flavonoids,widely exising in the natural world, have multiple pharmacological activities.This paper summarizes flavonoids as promising multi-targeted anti-AD candidates according to the reported references previonsly published,which could provide important evidences in the development of anti-AD durgs.
