Advances in research of protein tyrosine phosphatase 1B and its inhibitors
10.11665/j.issn.1000 -5048.20180101
- VernacularTitle:蛋白酪氨酸磷酸酶1B及其抑制剂的研究进展
- Author:
Zhong YUAN
1
;
Zhuo CHEN
;
Qianbin LI
;
Gaoyun HU
Author Information
1. 中南大学湘雅药学院
- Keywords:
protein tyrosine phosphatase 1B;
type 2 diabetes mellitus;
obesity;
inhibitors;
progress
- From:
Journal of China Pharmaceutical University
2018;49(1):1-9
- CountryChina
- Language:Chinese
-
Abstract:
Protein tyrosine phosphatase 1B(PTP1B),a member of protein tyrosine phosphatases(PTPs),plays a key role in the negative regulation of insulin and leptin signalings.Recent studies showed that PTP1B had an important connection with endoplasmic reticulum(ER)stress, pancreatic beta cells proliferation and insulin secretion,and is closely related to the pathological process of type 2 diabetes mellitus(T2DM)and obesity. Therefore,PIP1B targeted inhibitors have become a research hotspot in the treatment of these metabolic disea-ses.Based on the structural features of PTP1B and its relationship with T2DM and obesity,PTP1B inhibitors were classified according to the sites of binding.Their latest research advances were reviewed in this paper,providing a reference for the development of anti-T2DM and anti-obesity drugs targeting PTP1B.
