Determination of dabigatran etexilate mesylate and related substances by HPLC
10.11665/j.issn.1000-5048.20170612
- VernacularTitle:高效液相色谱法检测甲磺酸达比加群酯及有关物质
- Author:
Xiaonan XUE
1
;
Zhengjin ZHANG
;
Qiang ZOU
;
Chao YAN
Author Information
1. 上海交通大学药学院
- Keywords:
dabigatran etexilate mesylate;
related substances;
HPLC;
determination of content
- From:
Journal of China Pharmaceutical University
2017;48(6):711-714
- CountryChina
- Language:Chinese
-
Abstract:
In order to research the related substances of dabigatran etexilate mesylate,seven related compounds were synthesized and the related detection methods were established (Using XBridge C18 as the column,methanol-0.01mol/L potassium dihydrogen phosphate as the mobile phase Gradient elution,detection wavelength of 310 nm).The solvents and the injection volume were also screened.Results showed that the established method could separate the dabigatran etexilate mesylate and seven compounds completely,and the reproducibility was good and the accuracy was high,which was suitable for the detection of the related substances of dabigatran etexilate mesylate.
