Advances in self-assemblied DNA nanocages as drug delivery systems
10.11665/j.issn.1000-5048.20170605
- VernacularTitle:DNA自组装纳米笼用于药物递送系统的研究进展
- Author:
Xiu HAN
1
;
Xiaole QI
;
Zhenghong WU
Author Information
1. 中国药科大学药学院药剂系
- Keywords:
DNA nanocage;
self-assembly;
modification;
targeted drug delivery;
advances
- From:
Journal of China Pharmaceutical University
2017;48(6):663-669
- CountryChina
- Language:Chinese
-
Abstract:
DNA nanocages are nanoscale three-dimensional polyhedral structures formed by self-assembled oligonucleotide strands by base pairing.DNA nanocages,especially the tetrahedron DNA nanocages,were proved to be potential nanocarriers for drug delivery,due to their good stablility,high compatibility,intracellular ablility and hollow cavity for modification and drug loading..In this paper,we reviewed the structural characteristics,synthetic methods and targeted modification of DNA nanocages,as well as their development and application in drug carriers,biological imaging,in vitro diagnosis and materials science.
