Recent progress on crystallizations of amorphous pharmaceutical solids
10.11665/j.issn.1000-5048.20170604
- VernacularTitle:无定形态药物结晶行为的研究进展
- Author:
Qin SHI
1
;
Ting CAI
Author Information
1. 中国药科大学药学院药剂系
- Keywords:
amorphous drugs;
crystallization;
surface;
glass;
molecular mobility;
stability
- From:
Journal of China Pharmaceutical University
2017;48(6):654-662
- CountryChina
- Language:Chinese
-
Abstract:
Compared to their crystalline form,amorphous drugs exhibit higher solubility and faster dissolution rate and thus enhancing oral bioavailability of poorly water soluble drugs.However,since the amorphous form is thermodynamically unstable relative to the crystalline form,amorphous solids tend to crystallize over time and subsequently negate their advantages.This review briefly describes fundamental aspects of amorphous substances and highlights the recent advances of fast crystallization behaviors.Understanding the inherent crystallization mecha nisms of amorphous materials is of utmost importance in order to control the physical stability and lead to efficient formulation development of amorphous pharmaceutical solids.
