Changes of serum anti-schistosome antibody levels in schistosomiasis japoni-ca patients after treatment
10.16250/j.32.1374.2017065
- VernacularTitle:日本血吸虫病治疗后血清抗体消长观察
- Author:
He-Hua HU
1
;
Xia ZHANG
;
Chun-Bin ZHANG
;
Yi-Bin YAO
;
Cai-Xia CUI
;
Xia LI
;
Xiao-Hong WEN
;
Jun LIU
;
Chuan-Yun XIAO
;
Xiong LIU
;
Chun-Li CAO
Author Information
1. 湖北省江陵县血吸虫病预防控制所、中国疾病预防控制中心寄生虫病预防控制所湖沼型血吸虫病流行区血防实验基地 江陵434100
- Keywords:
Schistosomiasis japonica;
Marshland and lake schistosomiasis endemic region;
Antibody titer;
Evaluation of cu-rative effect
- From:
Chinese Journal of Schistosomiasis Control
2018;30(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of serum anti-schistosome antibody titers in schistosomiasis japonica pa-tients after treatment,in order to provide the evidence for formulating the schistosomiasis surveillance program in marshland and lake regions.Methods Upon prospective cohort study,the stool examination positive schistosomiasis patients and blood exami-nation positive suspected patients(the titer was more than 1:80,including 1:80)were selected as the research objects in Jian-gling County in 2014,and they received the 2-day praziquantel therapy.Half year,one year and two years after the treatment, their blood samples and fecal samples were collected for IHA anti-schistosome antibody detections and schistosome egg and mira-cidium detections. Results In 2014,the stool examination positives were 251,and the majority of them were over 41 years old,accounting for 93.23%(234/251);581 cases of high antibody titers were detected by the IHA method,and the majority of them were over 41 years old,accounting for 89.16%(518/581).Half year,one year and two years after the treatment,among the stool examination positives,the negative conversion rates of stool positives were 99.60%(250/251),100%(239/239)and 100%(234/234)respectively and the negative conversion rates of antibody positives were 21.91%(55/251),64.11%(156/239)and 76.89%(193/234)respectively.In the high antibody titer positives,the negative conversion rates were 38.04%(221/581),64.11%(359/560),and 77.86%(429/551)respectively,Half year,one year and two years after the treatment.There were statistically significant differences among the antibody negative conversion rates by χ2test(χ2=77.538,183.412,25.469 respectively,all P<0.001).The geometric mean values of antibody titers of different durations between 2 groups were analyzed by 2-independent-samples T test,and the geometric mean values of antibody titers between the 2 groups were different before the treatment(t=23.576,P<0.01),but the geometric mean values of antibody titers between the 2 groups were not different 6 months,1 year and 2 years after the treatment(t=-0.046,1.165, -0.132,P=0.964, 0.245,0.895 respectively). Conclu-sions The levels of serum anti-schistosome antibody degrade slowly in schistosomiasis japonica patients after the treatment, and the results of IHA tests cannot distinguish the current schistosome infection from previous schistosome infection.Therefore, it is necessary to develop the specific diagnostic technology for schistosome infection in order to meet the need of monitoring.
