Circadian system:new target for the treatment of Parkinson's disease

VernacularTitle:生物节律:帕金森病治疗的新靶点
Author: Jiahe BAI ¹ ; Weiping JU ; Yong-Peng YU
Author Information

1. 青岛大学附属威海市中心医院神经内科
Keywords: Parkinson's disease; Circadian rhythm; Target; Clock genes
From: Chinese Journal of Behavioral Medicine and Brain Science 2018;27(11):1052-1056
CountryChina
Language:Chinese
Abstract: It was widely believed that disorders of circadian system were caused by neurodegenera-tive diseases. With the deepening of research,many scholars believed that disorders of circadian system may affect the occurrence and development of neurodegenerative diseases such as Parkinson's disease. 'Parkinson 's disease' and 'Circadian rhythm' were used as the key words of retrieval performance in the databases such as Pubmed,CNKI,Wanfang and so on,and the papers which were closely related with the theme were select-ed. The epidemiology,etiology and pathogenesis,clinical manifestations and the role of circadian system reg-ulation in PD were reviewed. The results show that the disorders of circadian system could be regulated by bright light therapy,melatonin and stem cell therapy,music therapy,and deep brain stimulation. Based on the theory of time medicine,combining the regulation of circadian system with the classical treatment of PD may provide a new breakthrough point for PD treatment. The disorders of circadian system is expected to be-come a new target for PD therapy.