Progress of bone marrow mononuclear cells transplantation in acute ischemic stroke

VernacularTitle:骨髓单个核细胞移植治疗急性脑梗死研究进展
Author: Xiaojie FU ¹ ; Sheng GUAN ; Haowen XU ; Yongjie YUAN ; Nan LI ; Jianping WANG
Author Information

1. 郑州大学第一附属医院神经介入科
Keywords: Bone marrow mononuclear cells; Acute ischemic stroke; Transplantation
From: Chinese Journal of Behavioral Medicine and Brain Science 2018;27(11):1047-1051
CountryChina
Language:Chinese
Abstract: Cellular therapy in acute ischemic stroke (AIS) is a research hotspot in the field of neu-roscience in recent years. Compared with other cells,bone marrow mononuclear cells (BMMNCs) are one of the most attractive therapeutic cells because BMMNCs can be rapidly isolated from bone marrow,are enriched with stem cells and permit autologous applications. Numerous basic researches showed that BMMNCs trans-plantation can decrease infarct volume and promote neurological outcomes in animal stroke model,indicating BMMNCs transplantation may has therapeutic values in acute ischemic stroke,and the transformation from basic research to clinical applications is on the key phase. In this paper,the progress of BMMNCs transplan-tation is reviewed in acute ischemic stroke on the aspects of BMMNCs component,methods of purification, route of transplantation,therapeutic mechanisms and problems from basic research to clinical application.