Gender differences of plasma glial cell line-derived neurotrophic factor levels in patients with major depressive disorder
10.3760/cma.j.issn.1674-6554.2018.11.007
- VernacularTitle:重性抑郁障碍患者血浆胶质细胞源性神经营养因子水平的性别差异
- Author:
Jiaze SUN
1
;
Lingtao KONG
;
Yanqing TANG
;
Fei WANG
;
Yange WEI
;
Feng WU
Author Information
1. 中国医科大学附属第一医院精神医学科
- Keywords:
Major depressive disorder;
Glial cell line-derived neurotrophic factor;
Gender
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(11):993-996
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate gender differences of plasma glial cell line-derived neurotro-phic factor (GDNF) levels in patients with major depressive disorder (MDD). Methods MDD subjects (male 20,female 36) and healthy controls (HCs) (male 35,female 45) were divided into four groups by gender. Plasma levels of GDNF were measured and compared in different gender groups. The clinical symp-tom severity of MDD patients was evaluated by 17-item Hamilton Depression Scale (HAMD-17) and Hamil-ton Anxiety Scale (HAMA-17). Results (1)The plasma GDNF level in male patients with major depres-sive disorder (( 1. 55 ± 0. 43 ) pg/ml ) was significantly lower than that in healthy controls (( 1. 86 ± 0. 50)pg/ml,F=4. 64,P=0. 036). There was no significant difference in GDNF level between female de-pression patients((1.62±0.46)pg/ml)) and female healthy control((1. 64±0. 48)pg/ml,F=0. 18,P=0. 672). In HCs,the GDNF level of male was significantly higher than that of female((1. 86±0. 50)pg/ml, (1. 64±0. 48)pg/ml,F=2. 04,P=0. 045). There was no significant difference in GDNF level between male and female patients(P>0. 05). (2) GDNF level in male patients with major depressive disorder was nega-tively correlated with HAMA score(r=-0. 388,P=0. 034). Conclusion The expression of GDNF is affect-ed by sex factors,which may be related to the different pathogenesis of MDD.
