Clinical study on diazepam combined with olanzapine in treatment of agitation in alcohol withdrawal delirium tremors
10.3760/cma.j.issn.1674-6554.2018.10.010
- VernacularTitle:地西泮联合奥氮平治疗震颤谵妄伴激越行为的临床研究
- Author:
Kai ZOU
1
;
Jing YUAN
;
Feng YI
;
Jia MEI
;
Jingyu MAO
;
Yangyang ZHANG
;
Xingfu ZHAO
Author Information
1. 南京医科大学附属无锡市精神卫生中心普通精神科
- Keywords:
Delirium tremors;
Agitation behavior;
Diazepam;
Olanzapine
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(10):911-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of diazepam combined with olanzapine in treatment of agitation symptoms in patients with alcohol withdrawal delirium tremors( DT) . Methods Total-ly 60 inpatients with DT according to CCMD-3 were enrolled in a 7-day,with 30 patients in the diazepam group ( control group) and 30 patients in diazepam combined with olanzapine group ( research group) . The delirium rating scale( DRS-R-98) was used to evaluate the severity of the delirium symptoms. The positive and negative syndrome scale excited component( PANSS-EC) was used to assess the agitation symptoms. The treatment emergent symptom scale ( TESS) was used to assess the safety and the vital signs. Results There was no significant difference in the delirium recovery time between the two groups(M(QR):24 h(24 h)vs 24 h(6 h))(Z=-0. 45,P=0. 65). The PANSS-EC score in research group(17. 00±2. 67) was significant low-er than that in control group(19. 80±2. 43) at the 6 hours after treatment(t=4. 26,P<0. 01),but there were no significant difference between the two groups at the baseline,24 h,48 h and 72 h(P>0. 05) . One case of dizziness,2 cases of lethargy in the control group;1 case of nasal congestion,5 cases of drowsiness,3 cases of constipation, 3 cases of dry mouth, 1 case of abnormal liver function in the research group. Conclusion The combination of olanzapine with diazepam can not reduce the recovery time of DT,but can quickly improve the agitation behavior.
