Chondroid tenosynovial giant cell tumor of the toe: A case report.
- Author:
Seung Myoung SON
1
;
Yong Moon LEE
;
Hyang Mi SHIN
;
Jae Gul CHUNG
;
Jongwon CHUNG
;
Ok Jun LEE
Author Information
1. Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-763, Korea. ok5218@hanmail.net
- Publication Type:Case Report
- Keywords:
tenosynovial giant cell tumor;
giant cell of tendon sheath;
nodular tenosynovitis;
chonroid, metaplasia
- MeSH:
Elbow;
Foot;
Giant Cell Tumors*;
Giant Cells;
Hand;
Hemosiderin;
Hip Joint;
Humans;
Metaplasia;
Middle Aged;
Staphylococcal Protein A;
Tendons;
Toes*;
Walking
- From:Journal of Biomedical Research
2014;15(1):49-52
- CountryRepublic of Korea
- Language:English
-
Abstract:
Localized tenosynovial giant cell tumor (TGCT) usually occurs in the hand and foot regions. However, localized TGCT with extensive cartilaginous metaplasia is rare, especially in the tendon sheath of the toe. Here, we report a case of localized TGCT with cartilaginous metaplasia in a 57-year-old man. The tumor presented as a lobular mass measuring 2.2 cm in its greatest dimension and arose in the flexor digitorum tendon sheath of the right 2nd toe. Clinically, the mass was palpable 1 year ago and brought pain during walking. Microscopically, the mass was composed of focal conventional TGCT and cartilaginous components. The conventional TGCT areas consisted of mononuclear cells, multinucleated giant cells, and hemosiderin deposition. The chondroid areas were extensive and comprised more than 90% of the whole tumor. In this case, the mononuclear cells in the conventional TGCT areas showed focal immunohistochemical staining for podoplanin and S100 protein as well as diffuse staining for CD68, which is consistent with the staining pattern of conventional TGCT. The mononuclear cells in the chondroid areas were focal positive for podoplanin and diffuse positive for S100 protein. Chondroid metaplasia in diffuse TGCT has been reported in 10 cases involving the temporomandibular, elbow, and hip joints. However, there has been no report of a localized form of chondroid TGCT involving an extra-articular region.
