Effect of mood stabilizer on gray matter volume in patients with bipolar disorder Ⅰ
10.3760/cma.j.issn.1674-6554.2018.09.008
- VernacularTitle:心境稳定剂对双相障碍Ⅰ型患者大脑灰质体积的影响
- Author:
Erni JI
1
;
Yuanhan BAI
;
Linling LI
;
Fei TANG
;
Daihui PENG
;
Yiru FANG
;
Haiyan CHEN
;
Haichen YANG
Author Information
1. 深圳市精神卫生中心情感障碍科
- Keywords:
Bipolar disorder;
Voxel-based morphology;
Mood stabilizer
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(9):808-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormal change of gray matter volume in patients with euthymic bipolar disorder Ⅰ (BD-Ⅰ),and to elucidate the relationship between the use of different mood stabilizers and brain structure variations.Methods Voxel-based morphometry (VBM) was used to analyze the volume of local gray matter in 35 patients with BD-Ⅰ and 30 healthy controls(HC).The patients were divided into BD-Ⅰ with lithium group and BD-Ⅰ with valproate group according to different mood stabilizers.The volume differences of gray matter of the three groups were compared by one-way ANOVA.Results Compared with HC,BD-Ⅰ patients showed significantly reduced gray matter volume in the medial frontal cortex (MNI (x,y,z):2,34,-18),orbital frontal cortex (MNI(x,y,z):-32,22,-4),frontal operculum (MNI(x,y,z):38,18,4) and insula cortex (MNI(x,y,z):-32,22,-4) (P＜0.05).There was no significant difference in thevolume of gray matter between BD-Ⅰ with lithium group and BD-Ⅰ with valproate group(P＞0.05).Conclusion Emotional disturbance in patients with BD-Ⅰ may be associated with reduced gray matter volume in the medial frontal cortex,orbital frontal cortex,frontal operculum and insula cortex.There are not significant difference about the effects of lithium carbonate and valproate on cerebral gray matter volume in patients with BD-Ⅰ.
