Correlation between serum homocysteine level and mild cognitive impairment in patients with Parkinson's disease
10.3760/cma.j.issn.1674-6554.2018.08.006
- VernacularTitle:帕金森病患者轻度认知功能障碍与血清同型半胱氨酸水平的相关性
- Author:
Na LIU
1
;
Yi LIU
;
Shuyan TONG
;
Dianshuai GAO
Author Information
1. 徐州医科大学附属医院神经内科
- Keywords:
Parkinson's disease;
Mild cognitive impairment;
Homocysteine level in serum
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(8):700-705
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between mild cognitive impairment (PD-MCI) and serum homocysteine (Hcy) in patients with Parkinson's disease.Methods 85 patients with PD (43 with PD-MCI,42 with PDN) as the observation group and 43 healthy elderly patients as the control group.The demographic information,clinical and neuropsychological assessments were conducted and the Hcy of fasting venous blood were detected in all subjects.The I-Icy level and its associated factors were also analyzed in the PD group.Results Serum levels of Hcy in the PD patients((13.53±2.29) μmol/L) were higher than those in the HC group((11.77±1.56) μmol/L),the difference was statistically significant (t=4.57,P ＜0.05).There was significant difference in serum Hcy levels among HC group,PDN group ((12.85 ± 1.88) μmoL/L) and PD-MCI group((14.22±2.47) ±mol/L) (F=16.13,P＜0.01).Hcy level of the PDN group was higher than that of the HC group (P＜0.05),and PD-MCI group was higher than PDN group (P＜0.05).Serum levels of Hcy in patients with PD-MCI were significantly associated with UPDRS-Ⅲ (r=0.305),H-Y (r=0.313),LEDD (r=0.424),MMSE (r =-0.470),MoCA (r=-0.503),duration of connection test B (r =0.617) and semantic fluency tests (r=0.557) (all P＜0.05).Conclusion Elevated serum Hcy levels are expected to be biomarkers for predicting PD-MCI.
