Pleiotropic action of genetic variation rs1344706 in ZNF804A on brain structure and function in pa-tients with schizophrenia
10.3760/cma.j.issn.1674-6554.2018.06.016
- VernacularTitle:ZNF804A基因rs1344706多态性与精神分裂症患者脑结构功能的关系
- Author:
Shuai WANG
1
;
Zi CHEN
;
Yanzhang LI
;
Yan WU
Author Information
1. 成都医学院心理学院
- Keywords:
Zinc finger protein 804A;
Brain structure and function;
Schizophrenia;
Meta a-nalysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(6):565-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between the ZNF804A gene genetic variation poly-morphism rs1344706 and brain structure and function in patients with schizophrenia. Methods Literature search was conducted in Pubmed and other databases,the processes were performed in strict accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,then the Comprehensive Meta-Analysis software was used for meta-analysis. Results Schizophrenia patients with rs1344706 risk al-lele had lager gray matter in the amount of brain regions including frontal lobe (z＝3.445,P＝0.001),tempo-ral lobe (z＝2.140,P＝0.032) and other brain regions; healthy controls with the risk allele had smaller gray matter and regional activity in the frontal lobe ( gray matter: z＝－2.008, P＝0.045, regional activity: z＝－4.036,P＜0.01) and other regions. Sensitivity analysis was stable,but publication bias existed in a few ana-lyses of indexes. Conclusion The risk allele in ZNF804A gene rs1344706 has positive effects on the brain structure in patients with schizophrenia,but negative effects on the brain structure and function in the healthy individuals.
