Study on functional connectivity between the subgenual anterior cingulate cortes and limbic cortices in predicting the efficacy of early antidepressant treatment outcome
10.3760/cma.j.issn.1674-6554.2018.06.004
- VernacularTitle:膝下前扣带回?边缘相关脑区功能连接对抗抑郁疗效的早期预测作用
- Author:
Qiang WANG
1
,
2
;
Shui TIAN
;
Hao TANG
;
Rui YAN
;
Jiabo SHI
;
Yu CHEN
;
Qing LU
;
Zhijian YAO
Author Information
1. 210093 南京,南京大学医学院
2. 210029 南京,南京医科大学附属脑科医院心境障碍科(江苏省抑郁症诊疗中心)
- Keywords:
Major depressive disorder;
Theta wave;
Curative effect;
Magnetoencephalogra-phy;
Functional connectivity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(6):499-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of functional connectivity( FC) between the subgenual anterior cingulate cortes(sgACC) and limbic cortices in predicting the efficacy of early antidepressant treat-ment. Methods Resting state magnetoencephalography( MEG) data were collected from 32 patients with major depressive disorder(MDD) and 20 matched healthy control subjects at baseline.According to whether the HAMD17total score reduction rate reached 50% after 2 weeks,the patients were divided into responder group and non-responder group.The difference of the FC,the relationship between the FC and the change rate of HAMD17were explored. Results Compared with controls,MDD patients showed decreased connectivity of the sgACC with the right hippocampus(MNI coordinate:x＝30,y＝－3,z＝－24; F＝5.11,P＝0.028),the right amygdala(MNI coordinate:x＝22,y＝－2,z＝－15; F＝6.90,P＝0.012) and the left amygdala(MNI coordi- nate:x＝－24,y＝－6,z＝－16; F＝5.75,P＝0.020).Compared with non-responders,the connectivity of the sgACC with the right hippocampus(MNI coordinate:x＝30,y＝－3,z＝－24;F＝8.74,P＝0.0065),the right a-mygdala(MNI coordinate:x＝22,y＝－2,z＝－15; F＝12.417,P＝0.0016) were higher in responders.Pretreat-ment connectivity of the sgACC with the right hippocampus(r＝－0.50,P＝0.0066),the right amygdala(r＝－0.56,P＝0.0018) were negatively correlated with clinical improvement.ROC analyses confirmed the value of the connectivity of sgACC with the right hippocampus(area under curve(AUC)＝0.71,P＝0.042),the right amygdala(AUC＝0.73,P＝0.029) in classifying responders versus non-responders in 2 weeks of treatment. Conclusion The decreased FC of the sgACC with the right hippocampus and the right amygdala at baseline is associated with a better improvement,which can potentially serve as a treatment outcome biomarker in ear-ly curative effect of depression.
