Cognitive functions in the first degree relatives of patients with schizophrenia in China:a meta-analysis
10.3760/cma.j.issn.1674-6554.2018.05.018
- VernacularTitle:中国精神分裂症患者一级亲属认知功能的meta分析
- Author:
Wen HUANG
1
;
Chongni ZHANG
;
Maorong HU
Author Information
1. 南昌大学第一附属医院心身医学科
- Keywords:
Schizophrenia;
First-degree relatives;
Cognitive function;
Meta-analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(5):470-475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cognitive functions in first-degree relatives of patients with schizophrenia by meta-analysis. Methods Collect case-control studies of cognitive function in first-degree relatives of patients with schizophrenia,then extract data and assess the risk of bias of included studies,and use RevMan 5.3 to perform meta-analysis. Results A total of 27 studies involving 1708 people were includ-ed. Trail Marking A test(MD=3.59,P<0.01) and B test (MD=12.71,P=0.02),Stroop Color test((MD=-7.22,P<0.01),Stroop Color-Word test(MD=-7.25,P<0.01),Digit Symbol Coding test(MD=-7.29,P<0.01),Digit Span test(MD=-1.17,P<0.01),Hopkins Verbal Leaning test-Revised(MD=-4.58,P<0.01), Verbal Fluency test(MD=-2.92,P<0.01),Hanoi Tower(MD=-5.38,P<0.01),the number of corrected of WCST(MD=-3.10,P<0.01),number of completed categories of WCST (MD=-0.74,P<0.01),Persevera-tive Errors of WCST (MD=4.82,P<0.01) and Nonperseverative Errors of WCST (MD=8.00,P<0.01) scores between the first-degree relatives groups(FDR)and health control groups (HC)showed significant differences. Conclusion Cognitive impairment appears in the first-degree relatives populations of patients with schizophrenia,including the attention,verbal learning,working memory,and executive function.
