Analysis of the influencing factors for the cognitive deficits in schizophrenic patients with diabetes
10.3760/cma.j.issn.1674-6554.2018.03.012
- VernacularTitle:精神分裂症并发糖尿病患者认知功能损害影响因素分析
- Author:
Baohua ZHANG
1
;
Xiaole HAN
;
Zhiren WANG
;
Shurong JIANG
;
Xiaoyu ZHU
;
Limin XIN
;
Yun BIAN
;
Xingjie YANG
;
Qingyan YANG
;
Fude YANG
;
Yunlong TAN
Author Information
1. 北京回龙观医院心身医学科
- Keywords:
Diabetes;
Schizophrenia;
Cognitive deficits;
Influential factors
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(3):246-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors of the cognitive deficits in schizophrenic patients with diabetes.Methods 578 inpatients with schizophrenia and 400 healthy adults were collected.578 schizophrenic patients were divided into schizophrenia group with type 2 diabetes (combined group,n=277) and schizophrenia without type 2 diabetes (single disease group,n=301).The cognitive function of all subjects were examined by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).The clinical symptoms of patients with schizophrenia were measured with the Positive and Negative Syndrome Scale (PANSS).Fasting glucose,lipids,hemoglobin A1c (HbA1c) and insulin levels were measured.Results The total score and factor scores of RBANS in the combined group were lower than those in the healthy control group (total score (70.51 ± 14.43) vs (80.04 ± 15.14),immediate memory (62.65 ± 16.81) vs (75.66± 17.33),visual span(83.60±20.81) vs (87.61 ± 15.61),verbal function(85.58± 14.64) vs (93.88± 13.10),attention function (73.66± 17.52) vs (87.42±20.37),delayed memory(75.27± 17.80) vs (86.27± 15.27),all P＜0.05).The total score of RBANS,immediate memory and attention function factor were lower in the combined group than that in the single disease group ((70.51±14.43) vs (75.02±15.25),(62.65±16.81) vs (67.37±19.12),(73.66±17.52) vs (84.17±15.22),all P＜0.05).Multiple linear stepwise regression analysis showed that education,negative symptoms,positive symptoms,BMI,HbAc 1,course of disease and antipsychotic type were the influencing factors of cognitive impairment in schizophrenic patients with diabetes.Conclusion The cognitive impairment of schizophrenic patients with diabetes is more serious and affected by many factors.Targeted early intervention can help reduce cognitive impairment.
