Correlation of polymorphism of glial high-affinity glutamate transporter (SLC1A3) gene and non-suicidal self-injury in adolescents
10.3760/cma.j.issn.1674-6554.2018.03.007
- VernacularTitle:神经胶质高亲和力谷氨酸转运体基因多态性与青少年非自杀性自伤的关联研究
- Author:
Ming AI
1
;
Jiajia JIN
;
Liuyi RAN
;
Su HONG
;
Suya WANG
;
Qi ZHANG
;
Jianmei CHEN
;
Li KUANG
Author Information
1. 重庆医科大学附属第一医院精神科
- Keywords:
Adolescent;
Non-suicidal self-injury;
Glial high-affinity glutamate transporter (SLC1A3)
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(3):222-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between polymorphisms (SNPs) of locus rs2269272 of glial high-affinity glutamate transporter (SLC1A3) gene and suicide attempt among Chinese adolescents.Methods iMLDRTM genotyping technology was used to detect the polymorphism of rs2269272 SLC1A3 gene loci in 55 suicide attempters and 112 healthy controls,and survival analysis was applied to analyze the relationship between allele (T) and the age of suicide attempt.Results The differences of rs2269272 locus allele distribution between two groups were statistically significant(x2=4.208,P=0.040),but genotype distribution of two groups had no significantly differences(x2 =4.011,P=0.135).Non-suicidal self-injury adolescents with locus rs2269272 (15.6 ± 0.4) were younger than adolescents without locus rs2269272(16.4±0.7),but the difference was not statistically significant.Conclusion Preliminary findings suggest that rs2269272 SLC1 A3 may be relevant to non-suicidal self-injury acts,and rs2269272 locus allele is not related to earlier suicide attempt.
