Association study between T-182C and G1287A polymorphisms in norepinephrine transporter gene and schizophrenia
10.3760/cma.j.issn.1674-6554.2018.02.012
- VernacularTitle:去甲肾上腺素转运体基因T-182C和G1287A多态性与精神分裂症的关联研究
- Author:
Xiaofeng ZHAO
1
;
Qian LIU
;
Jianyue PANG
;
Suxia CAO
;
Hengfen LI
Author Information
1. 郑州大学第一附属医院精神医学科
- Keywords:
Norepinephrine transporter gene;
Single nucleotide polymorphism;
Schizophrenia
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2018;27(2):160-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether the norepinephrine transporter(NET) gene T-182C and G1287A polymorphisms are involved in the etiology of schizophrenics among the Chinese Han population.Methods 249 schizophrenics(case group) and 309 healthy physical examiners(control group) of the Chinese Han population were collected.Ligase detection reaction was used to detect the genotype distributions and allele frequencies of NET rs2242446 and rs5569 polymorphisms in the two groups.The genotype distributions and allele frequencies of these two single nucleotide polymorphisms (SNPs) were also compared in the case and control groups.Results In the case group,the TF genotype of the NET gene loci rs2242446 was the most,48.6％,and the CC genotype of which was the least,8.4％.In the control group,the CT genotype was the most,47.9％,and the C C genotype was the least,11.3％,the minimum allele frequency was 29.9％.In the case group,the GG genotype of the NET gene loci rs5569 was the most,46.2％,and the CC genotype was the least,9.6％.In the control group,GG genotype was the most,51.5％,and the AA genotype was the least,10.3％,and the minimum allele frequency was 29.4％.No significant differences in the genotype and allele distribution of NET rs2242446 and rs5569 were found in Chinese-Han patients with schizophrenia and control participants (all P＞ 0.05).In gender-specific analyses,similarly,no significant differences were found for rs2242446 and rs5569 genotype and allele distributions in either the male or the female case-control comparisons (all P＞ 0.05).Conclusion The NET rs2242446 and rs5569 polymorphisms are not associated with schizophrenia in Chinese Han population.
