The role of microRNA-137 gene in schizophrenia

VernacularTitle:微小RNA-137基因与精神分裂症
Author: Ying CHENG ^{1
,

2} ; Peijun JU ; Donghong CUI
Author Information

1. 200030上海,上海交通大学医学院附属精神卫生中心
2. 201108上海,上海市重性精神病重点实验室
Keywords: microRNA-137; Schizophrenia; Single nucleotide Polymorphism
From: Chinese Journal of Behavioral Medicine and Brain Science 2018;27(1):85-88
CountryChina
Language:Chinese
Abstract: Schizophrenia is a chronic devastating psychiatric disorder,which severely damages pub-lic mental health. The pathophysiological mechanism of schizophrenia is complex and the etiology of schizo-phrenia is still unclear. Epidemiological study,twins study and family study show that genetic factors play a substantial part in the process of schizophrenia. Previous research indicates that there is a close association between microRNA-137 and schizophrenia,and that the ablation of microRNA-137 significantly affects clini-cal symptoms and prognosis of patients with schizophrenia. So it highlights the relationship between microR-NA-137 and schizophrenia,which reveals its special role in the etiological mechanism of schizophrenia,and may provides new perspective about the treatment of patients in schizophrenia.