The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery.
10.3349/ymj.2015.56.6.1671
- Author:
Ji Won JUNG
1
;
Byung Hoon CHUNG
;
Eung Kweon KIM
;
Kyoung Yul SEO
;
Tae Im KIM
Author Information
1. Department of Ophthalmology, Severance Hospital, Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Korea. tikim@yuhs.ac
- Publication Type:Original Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Non-steroidal anti-inflammatory drugs;
miosis;
ocular inflammation;
macular edema
- MeSH:
Aged;
Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage/pharmacology;
Benzophenones/*administration & dosage/pharmacology;
Bromobenzenes/*administration & dosage/pharmacology;
*Cataract;
*Cataract Extraction;
Female;
Humans;
Inflammation/prevention & control;
Ketorolac/*administration & dosage/pharmacology;
Lens Implantation, Intraocular;
Macular Edema/*prevention & control;
Male;
Middle Aged;
Miosis/*prevention & control;
Phacoemulsification;
Postoperative Complications/drug therapy;
Postoperative Period;
Premedication;
Treatment Outcome
- From:Yonsei Medical Journal
2015;56(6):1671-1677
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), bromfenac 0.1% or ketorolac 0.45%, relative to topical steroid alone in cataract surgery. MATERIALS AND METHODS: A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free ketorolac 0.45%; and Group 3, postoperative steroid only, as a control. Outcome measures included intraoperative change in pupil size, postoperative anterior chamber inflammation control, change in macular thickness and volume, and ocular surface status after operation. RESULTS: Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30+/-4.25, 4.87+/-6.03, and 12.47+/-12.24 microm in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in patients with diabetes mellitus (DM), compared to those without DM. In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of patients with or without DM. Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant. CONCLUSION: Adding preoperative and postoperative bromfenac 0.1% or ketorolac 0.45% to topical steroid can reduce intraoperative miosis, postoperative inflammation, and macular changes more effectively than postoperative steroid alone.
