A review of α7 nicotinic acetylcholine receptor and schizophrenia cognition

VernacularTitle:α7烟碱型乙酰胆碱受体与精神分裂症认知功能(综述)
Author: Ping ZHANG ¹ ; Wenjin DAI ; Zhiren WANG ; Shuping TAN ; Fude YANG ; Yunlong TAN
Author Information

1. 北京回龙观医院
Keywords: α7 nicotinic acetylcholine receptor; schizophrenia; cognitive function; review
From: Chinese Mental Health Journal 2018;32(4):324-328
CountryChina
Language:Chinese
Abstract: This paper briefly introduces the structure and function of α7nAChR, and mainly reviews the relevant researches about the relationship between a7nAChR and cognition of schizophrenia in the last ten years from molecule genetics and new targets of medication two aspects. It suggests that the abnormal α7AChR is involved in cognition impairment of schizophrenia, and the a7nAChR agonist is probably able to improve the impaired cognition in patients with schizophrenia. Furthermore, KAT-2 as a key enzyme acting on its endogenous antagonist KYNA is also promising to become a new drug target