Predictive Value of CHA2DS2-VASc Score for Contrast-induced Nephropathy After Elective Percutaneous Coronary Intervention in Patients With Coronary Heart Disease
10.3969/j.issn.1000-3614.2018.11.003
- VernacularTitle:CHA2DS2-VASc评分对冠心病患者择期经皮冠状动脉介入治疗术后对比剂肾病的预测价值
- Author:
Fei CHEN
1
;
Jing-Chao LU
;
Xiu-Chun YANG
;
Bing XIAO
;
Ya-Qiong JIN
;
Fan LIU
;
Wei CUI
Author Information
1. 河北医科大学第二医院 心内科 河北省心脑血管病研究所
- Keywords:
CHA2DS2-VASc score;
Coronary heart disease;
Percutaneous coronary intervention;
Contrast-induced nephropathy
- From:
Chinese Circulation Journal
2018;33(11):1049-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the predictive value of CHA2DS2-VASc score for contrast induced nephropathy (CIN) after percutaneous coronary intervention in patients with coronary heart disease. Methods: A total of 356 patients undergoing elective percutaneous coronary intervention were enrolled in this study. The patients were divided into two groups according to the CHA2DS2-VASc score: CHA2DS2-VASc score ≥ 3 (n=153) and ≤ 2 (n=203). Baseline data, incidence of CIN and major adverse cardiovascular events were analyzed and compared between the two groups. The predictive effect of CHA2DS2-VASc score was analyzed with receiver operating characteristic curve (ROC) and logistic regression analysis. Results: Left ventricular ejection fraction was significantly lower, baseline serum creatinine value was significantly higher, coronary lesions were more complex, contrast agent dosage used was significantly larger and the incidence of CIN was significantly higher in patients of the CHA2DS2-VASc score ≥ 3 group than in patients of CHA2DS2-VASc score ≤ 2 group (all Pvalues<0.05). Multivariate logistic regression analysis showed that CHA2DS2-VASc score≥3 was an independent predictor of CIN (OR=2.152, 95% CI: 1.261-3.987, P=0.032). The area under the curve of ROC of CHA2DS2-VASc score ≥ 3 for predicting CIN was 0.749 (sensitivity 76.9%, specificity 73.0%). Conclusions: CHA2DS2-VASc score could predict the CIN after percutaneous coronary intervention in patients with coronary heart disease, which could help us identify the high-risk patients of CIN and take preventive measures to reduce the incidence of CIN post percutaneous coronary intervention.
