Impact of Acquired Thrombocytopenia After Elective Percutaneous Coronary Intervention on Long-term Outcomes of Patients With Coronary Artery Disease
10.3969/j.issn.1000-3614.2018.11.002
- VernacularTitle:择期经皮冠状动脉介入治疗术后获得性血小板减少对患者远期预后的影响
- Author:
Shuai LIU
1
;
Yan-Yan ZHAO
;
Rui FU
;
Lei FENG
;
Cheng-Gang ZHU
;
Dong YIN
;
Ke-Fei DOU
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 冠心病中心
- Keywords:
Thrombocytopenia;
Percutaneous coronary intervention;
Mortality
- From:
Chinese Circulation Journal
2018;33(11):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the association between acquired thrombocytopenia and long-term clinical outcome among stable coronary artery disease patients undergoing elective percutaneous coronary intervention (PCI). Methods: We analyzed clinical data of 8 271 consecutive patients who underwent elective PCI in Fuwai Hospital from January 2013 to December 2013. Acquired thrombocytopenia was defined as platelet count <150×109/L after PCI in patients with normal baseline platelet count value. We compared data on demographic, clinical, laboratory, and 30-month outcome between non-thrombocytopenic and thrombocytopenic patients and identified the independent predictors of acquired thrombocytopenia post PCI. Results: Acquired thrombocytopenia developed in 654 (7.91%) patients (634 [7.67%] patients had mild thrombocytopenia, 20 [0.24%] patients had moderate or severe thrombocytopenia). Patients who developed thrombocytopenia had higher 30-month rate of all cause death (2.3% vs 1.0%, P=0.0086) and cardiogenic death (1.2% vs 0.5%, P=0.0261). Moderate or severe thrombocytopenia was associated with a 13-fold increased risk for cardiogenic death, 7-fold increased risk for stent thrombosis,11-fold increased risk for myocardial infarction compared with patients without thrombocytopenia. Conclusions: Acquired thrombocytopenia after PCI is common in stable coronary artery disease patients and is independently associated with increased risk of long-term adverse outcome in these patients.
