Prognostic Value of TIMI and GRACE Risk Scores for In-hospital Mortality in Chinese Patients With ST-segment Elevation Myocardial Infarction
10.3969/j.issn.1000-3614.2018. 06.003
- VernacularTitle:TIMI风险评分与GRACE风险评分对中国ST段抬高型心肌梗死患者院内死亡率的预测价值
- Author:
Xiao-Jin GAO
1
;
Jin-Gang YANG
;
Chao WU
;
Yue-Jin YANG
;
Hai-Yan XU
;
Ruo-Hua YAN
;
Yuan WU
;
Shu-Bin QIAO
;
Yang WANG
;
Wei LI
;
Yi SUN
;
Chen JIN
;
Qiu-Ting DONG
;
Yun-Qing YE
;
Xuan ZHANG
;
Rui FU
;
Hui SUN
;
Xin-Xin YAN
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 冠心病诊治中心
- Keywords:
ST-segment elevation myocardial infarction;
TIMI risk score;
GRACE risk score;
In-hospital mortality
- From:
Chinese Circulation Journal
2018;33(6):529-534
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:The purpose of this study was to evaluate the prognostic value of the Thrombolysis In Myocardial Infarction (TIMI) and Global Registry of Acute Coronary Events (GRACE) risk scores for in-hospital mortality in Chinese ST-segment elevation myocardial infarction (STEMI) patients. Methods:Present data are obtained from the prospective, multicenter Chinese AMI (CAMI) registry, 107 hospitals from 31 provinces, municipalities or autonomous districts in China took part in this study. From January 2013 to September 2014, 17886 consecutive ST-segment elevation myocardial infarction patients admitted to these 107 hospitals were enrolled. For each patient, TIMI and GRACE risk scores were calculated using specific variables collected at admission. Their prognostic value on the primary endpoint (in-hospital mortality) was evaluated. Results:Mean age of this patient cohort was (61.9±12.4)years, 76.5% (n=13685) patients were males. The in-hospital mortality was 6.4%(n=1 153)and the median length of hospital stay was 10.0 days. The incidence of cardiac arrest at admission were 4.3% (n=764). Coronary reperfusion therapy including fibrinolytic therapy(n=1782), primary percutaneous coronary intervention (n=7763) and emergent coronary artery bypass grafting (n=10) were applied to 9555 (53.4%) patients and the median of time to reperfusion was 300.0 minutes. The predictive accuracy of TIMI and GRACE for in-hospital mortality was similar:TIMI risk score (AUC) [area under the curve:0.7956; 95% confidence interval (95%CI:0.7822~0.8090)] and GRACE risk score (AUC:0.8096; 95%CI:0.7963~0.8230). Conclusions:The TIMI and GRACE risk score demonstrate similar predictive accuracy for in-hospital mortality and there are some disadvantages in risk stratification by these two risk scores for Chinese STEMI patients.
