Correlation Between Serum Inflammatory Biomarkers and Carotid Plaque Stability in Hypertensive Postmenopausal Women
10.3969/j.issn.1000-3614.2018.05.010
- VernacularTitle:绝经后女性高血压患者血清炎症因子与颈动脉斑块稳定性的相关性研究
- Author:
Li QU
1
;
Xiang-Heng LIU
;
Zuo-Hui YAN
;
Yong-Tao WEI
;
Zhi-Hui WANG
Author Information
1. 青岛市第八人民医院 体检中心
- Keywords:
Postmenopausal women;
Hypertension;
Vulnerable plaque;
Serum inflammatory factors
- From:
Chinese Circulation Journal
2018;33(5):463-468
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the relationships between the stability of carotid plaque and serum Lp-PLA2, A-FABP levels in hypertensive postmenopausal women. Methods: 195 postmenopausal women with hypertension were selected and divided into non-plaque group, stable plaque group and unstable plaque group according to the results of carotid intima-media thickness (IMT) and plaque types derived from color doppler ultrasonography. In addition, 40 healthy postmenopausal women were recruited as normal control group. The serum Lp-PLA2 and A-FABP levels of all subjects were measured. Lp-PLA2 and A-FABP levels were compared among four groups by One-Way ANOVA. Spearman correlation analysis and multiple logistic regression analysis were also performed. Results: Plaque group included 123 subjects (unstable plaque group: 29 cases; stable plaque group: 94 cases), and non-plaque group included 72 subjects. The average serum A-FABP level was significantly higher in unstable plaque group [(172.60±33.70) ng/L] than in non-plaque group[(133.04±29.49) ng/L], P<0.05. Serum Lp-PLA2 level was similar between the four groups, P>0.05. Serum A-FABP level was positively correlated with the carotid plaque (r=0.3446, P=0.0049);serum Lp-PLA2 level was not correlated with the carotid plaque (r=0.2058, P=0.0996). Multiple logistic regression analysis showed that high A-FABP level was associated with stable plaque in hypertensive postmenopausal women (P=0.040, OR=1.017, 95%CI: 1.001~1.033), which was also associated with unstable plaque in this population (P=0.003, OR=1.031, 95%CI: 1.010~1.052). Conclusions: The level of A-FABP is a determinant responsible for the occurrence and stability of carotid plaque among hypertensive postmenopausal women. There was no correlation between Lp-PLA2 level and the stability of carotid plaque in this patient cohort.
