Anti-aggregation Effect and Short-term Safety Evaluation of Low-dose Aspirin Therapy in the Elderly Chinese Population: a Multicenter Randomized Controlled Clinical Trial
10.3969/j.issn.1000-3614.2018.05.009
- VernacularTitle:小剂量阿司匹林对老年人血小板聚集率的影响和短期安全性评估:一项多中心随机对照临床研究
- Author:
Xia-Huan CHEN
1
;
Mei-Lin LIU
;
Ming-Fang QIN
;
Yan-Mei SUN
;
Tao TIAN
;
Jin-Qiao LI
;
Qing-Tan ZHANG
;
Jun LI
;
Yong-Jun MAO
;
Zhi-Sheng JIA
;
Zhi-Yong FANG
;
Zhi-Ping LV
;
Lian-Qi CUI
;
Chun-Hui GAO
;
Li-Na WANG
;
Yong-Ming HUI
;
Pei-Yan SHAN
;
Xiao-Ping CHEN
;
Peng-Fei YIN
Author Information
1. 北京大学第一医院 老年内科
- Keywords:
Chinese elderly;
Aspirin;
Formulation;
Platelet aggregation;
Bleeding
- From:
Chinese Circulation Journal
2018;33(5):457-462
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: This study aimed to observe the change of arachidonic acid-induced platelet aggregation rate (AA-Ag) and short-term adverse reactions after taking 50 or 100 mg/d aspirin(enteric-coated sustained-release formulation) or 100 mg/d aspirin (enteric-coated aspirin tablet)in the elderly Chinese population (aged 60 years or older). Methods: A total of 1 194 participants aged 60 or older, who should be recommended to take aspirin therapy due to medical reasons, were recruited and randomly assigned into three groups to receive enteric-coated sustained-release aspirin tablet (50 mg, once daily, group A), or 100 mg, once daily (group B) or enteric-coated aspirin tablet 100 mg once daily (group C), respectively. AA-Ag was measured after (14±3)days of aspirin treatment. Adverse events and bleeding events were recorded during the (28±3)days of follow-up. Results: The AA-Ag in group A (n=347), B (n=338) and C (n=332) post 14-day aspirin therapy were 6.65 (4.03,10.84)%, 5.89(3.22,10.03) % and 6.00(3.68,10.09) %, respectively (P>0.05). During the 28 days follow-up, the adverse events rate of group A (n=388), B (n=387) and C (n=385) was 3.87%,3.36%, and 7.95%, and the mild bleeding events rate was 3.09%, 2.33%, and 6.23%, respectively. Adverse events rate and mild bleeding events rate were significantly higher in group C than in group A and B (P<0.05). Conclusions: Compared with 100 mg-dose aspirin, 50 mg-dose aspirin achieves similar anti-platelet aggregation effect in this elderly Chinese population. The short-term adverse events and mild bleeding risk of aspirin with enteric-coated sustained-release formulation were fewer than that of enteric-coated formulation.
