Relationship Between Helicobacter Pylori Infection and Carotid Intima Thickness by Meta–analysis
10.3969/j.issn.1000-3614.2018.04.012
- VernacularTitle:幽门螺旋杆菌感染与颈动脉内膜中层厚度相关性的Meta分析
- Author:
Xue-Shan DONG
1
;
Zi-Long CHEN
;
Wen-Xin FAN
;
Ling CHEN
Author Information
1. 重庆医科大学 儿科学院
- Keywords:
Helicobacter pylori;
Carotid intima thickness;
Meta-analysis
- From:
Chinese Circulation Journal
2018;33(4):366-370
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the relationship between helicobacter pylori (Hp) infection and carotid intima thickness. Methods: We searched the databases of Pubmed, Embase, CNKI, VIP and Wanfang for published studies on the relationship between Hp infection and carotid intima thickness in China and abroad. 2 reviewers independently identified and enrolled the articles, extracted specific data and assessed the quality of reference by Jadad scale. Meta-analysis was conducted by Stata 12.0 Software. Results: A total of 9 case-control studies were enrolled, all the reference quality scores≥4 which included 694 subjects with Hp positive and 676 with Hp negative. Meta-analysis indicated that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects, standard mean difference (SMD)=0.803, 95% CI(0.686-0.919), P<0.05. Age related study presented that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects at the age≥60 years'population, SMD=1.296, 95%CI (1.125-1.467), P<0.05; carotid intima thickness was also higher in Hp positive subjects than Hp negative subjects at the age<60 years'population, SMD=0.379, 95%CI (0.220-0.537), P<0.05. Conclusions: Hp infection has been related to the thickness of carotid intima and it could make carotid artery intima thickening.
