Relationship Between Lung Ultrasound B Line and NT-proBNP, E/e' for Evaluating Pulmonary Edema in Acute Heart Failure Patients
10.3969/j.issn.1000-3614.2018.04.010
- VernacularTitle:应用肺部超声的肺水B线与N末端B型利钠肽原和E/e'评价急性心力衰竭患者肺水肿的相关研究
- Author:
Fei-Fei YANG
1
;
Qiu-Shuang WANG
;
Dang-Sheng HUANG
;
Li-Wei ZHANG
;
Dong SHEN
;
Yong-Jiang MA
;
Qiang CHEN
;
Min-Jun XIONG
;
Miao TIAN
Author Information
1. 中国人民解放军总医院第一附属医院 心内科
- Keywords:
Ultrasound;
Heart failure;
BNP
- From:
Chinese Circulation Journal
2018;33(4):355-359
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To analyze the relationship between lung ultrasound B line and NT-proBNP, E/e' in order to explore the accuracy of B lines for diagnosing pulmonary edema in patients with acute heart failure (AHF). Methods: A total of 124 AHF patients admitted in out hospital from 2016-02 to 2017-02 were enrolled. According to the number of B line, patients were divided into 3 groups: Mild pulmonary edema group, patients with B line<15, Moderate pulmonary edema group, 15≤B line<30 and Severe pulmonary edema group, B line≥30. Basic clinical condition and echocardiography parameters were compared among 3 groups; relationships between B line and NT-proBNP, E/e', EF, pulmonary artery pressure were analyzed respectively; the sensitivity and specificity for B-line diagnosing NT-proBNP≥5000 pg/ml and E/e'≥14 were evaluated by ROC curve analysis. Results: Compared with Mild and Moderate pulmonary edema groups, Severe pulmonary edema group had the severer NYHA grade, more wet rale, higher NT-proBNP level and more chest X-ray of pulmonary congestion, P<0.05. Compared with Mild pulmonary edema group, Moderate and Severe pulmonary edema groups had decreased LVEF, P<0.05; Severe pulmonary edema group showed increased diastolic function such as elevated E/A, pulmonary artery pressure and E/e',P<0.05.B line was positively related to NT-proBNP,E/e'and pulmonary artery pressure,negatively related to EF.B line had the best correlation to NT-proBNP (r=0.803, P<0.001), the next was E/e'(r=0.794, P<0.001) and the worst was pulmonary artery pressure (r=0.330, P<0.001). The cutoff values of B line for diagnosing NT-proBNP≥5000pg/ml and E/e'≥14 were both 30, the AUC of ROC=0.823 and 0.768 respectively. Conclusions: Lung ultrasound B line had good correlation to NT-proBNP and E/e', which could accurately assess the pulmonary edema in AHF patients.
