Relationship Between Cardiac Troponin Ⅰ Autoantibody and Left Ventricular Remodeling in Patients With Acute Myocardial Infarction
10.3969/j.issn.1000-3614.2018.04.003
- VernacularTitle:急性心肌梗死患者抗心肌肌钙蛋白Ⅰ自身抗体与左心室重构关系的分析
- Author:
Sang ZHOU
1
;
Hong-Ru WANG
;
Miao XUE
;
Wen-Jie YAO
;
Qian SHEN
;
Yu WU
;
Yong-Wen QIN
Author Information
1. 上海长海医院 心血管内科
- Keywords:
Myocardial infarction;
Cardiac troponin I;
Autoantibody;
Left ventricular remodeling
- From:
Chinese Circulation Journal
2018;33(4):322-326
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To analyze the relationship between cardiac troponin I autoantibody (cTnIAAb) and left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods: A total of 131 AMI patients were enrolled. Serum levels of cTnIAAb were measured by ELISA. Echocardiography was examined at the onset of AMI and 1 year follow-up evaluation. Taking left ventricular end systolic volume (LVESV) increasing>15% as left ventricular remodeling, 2-classified logistic stepwise regression analysis was conducted to screen 12 risk factors related to left ventricular remodeling. Results: 23/131(17.6%) patients were with positive cTnIAAb and 82.4% with negative cTnIAAb. 49 patients lost contact and in the rest 91 patients, 21.1% were with positive cTnIAAb. Clinical information was similar between cTnIAAb positive and negative patients upon admission, P>0.05; echocardiography showed that 28 (42.2%) patients had LVESV increasing>15% by 1 year follow-up study whom including 10 (52.6%) patients with cTnIAAb positive and 18 (25.4%) negative. 2-classified logistic stepwise regression analysis indicated that BNP peak and positive cTnIAAb were the risk factors for left ventricular remodeling (OR=1.001, 95% CI 1.001-1.002) and (OR=3.552, 95% CI 1.148-10.989), both P=0.028. Conclusions: Serum cTnIAAb was positive in part of AMI patients which was related to increased risk of left ventricular remodeling; cTnIAAb might be involved in pathophysiological process of left ventricular remodeling in AMI patients.
