Efficacy of FFR-guided PCI in Coronary Artery Disease Patients With SYNTAX score≥33 Unsuitable for CABG: A Single-center Clinical Observation
10.3969/j.issn.1000-3614.2018.03.002
- VernacularTitle:不适合冠状动脉旁路移植术的SYNTAX评分≥33分的冠心病患者在血流储备分数指导下行介入治疗的临床观察
- Author:
Zhi-Yong WU
1
;
Hong-Mei QI
;
Ye CHEN
;
Zhi-Yun ZHU
;
Xue-Hong ZHANG
;
Guo-Bo XIE
;
Zhi-Tang CHANG
;
Nan-Ping GONG
;
Mao-Sheng YU
;
Guo-Tai SHENG
;
Hua-Tai LI
Author Information
1. 江西省人民医院 心内科 江西省心血管病研究所
- Keywords:
SYNTAX score;
Coronary flow reserve;
Percutaneous coronary intervention;
Coronary artery bypass grafting
- From:
Chinese Circulation Journal
2018;33(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the short- and long-term clinical outcomes of fraction flow reserve (FFR)-guided percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients with SYNTAX score≥33 unsuitable for coronary artery bypass grafting (CABG). Methods: A total of 117 CAD patients admitted in our hospital from 2012-01 to 2015-06 were enrolled. Since SYNTAX score≥33, EuroSCORE>6, the patients were unsuitable for CABG and treated in 2 groups: Medication group, n=20 and PCI group, during FFR-guided PCI procedure, patients received ROTA or IVUS according to physician's experience, n=97. All patients were followed-up for at least 12 months. Meanwhile, taking "coronary stent and bypass", "CABG and PCI" as key words, we searched relevant documents in VIP Chinese science and technology journal full-text database, WanFang medical database, ChinaNet and Chinese biomedical literature database from 2012-01-01 to 2015-12-31, patients' outcomes were compared with the above references to explore the clinical benefit. Results: ① PCI group and Medication group had similar SYNTAX score and EuroSCORE, P>0.05. The common pathogenesis was LAD involvement, chronic occlusion was 31.3% (5/16) in patients with partial revascularization.②PCI group had 18.6% (18/97) incidence of major adverse cardiac and cerebral events (MACCE), 2 patients died during follow-up period and 9 received revascularization; Medication group had 60% (12/20) incidence of MACCE, 3 patients died during follow-up period; the difference between 2 groups showed statistical meaning, P<0.05.③There were 22 relevant documents retrieved as comparison; in our research, PCI group had similar incidence of MACCE to the documents, P>0.05; Medication group had increased incidence of MACCE than the documents, P<0.05. Conclusion: FFR-guided PCI could bring clinical benefit in CAD patients with SYNTAX score≥33 unsuitable for CABG.
