Meta-analysis for Vitamins Preventing Contrast Induced Nephropathy in Patients After Coronary Angiography
10.3969/j.issn.1000-3614.2018.02.017
- VernacularTitle:维生素预防冠状动脉造影术后对比剂肾病的Meta分析
- Author:
Geng TANG
1
;
Gen-Shan MA
Author Information
1. 东南大学医学院 临床医学系
- Keywords:
Vitamins;
Contrast induced nephropathy;
Meta-analysis
- From:
Chinese Circulation Journal
2018;33(2):181-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effects for vitamins preventing contrast induced nephropathy (CIN) in patients after coronary angiography (CAG) by Meta-analysis. Methods: We searched PubMed, Medline, Cochrane library central register of controlled trials and ClinicalTrails. gov from the database establishment to 2016-12 for CIN related references. According to enrollment and elimination standards, we chose eligible randomize control trail (RCT), extracted data and conducted a Meta-analysis using RevMan 5.3 statistical software. Results: A total of 11 RCTs with 1810 patients were enrolled which included in 2 groups: Vitamins group, n=951 and Placebo group, n=859. The average age of patients was (60-73) years and the male was (45.9-92.2) %. Meta-analysis showed that CIN occurrence rate in Vitamins group was lower than Placebo group (RR=0.54, 95% CI 0.39-0.73); compared with Placebo group, the incidence of CIN was decreased by 46% in Vitamins group. Using Vitamin C could decrease CIN occurrence rate (RR=0.58, 95% CI 0.37-0.90); compared with Placebo group, the incidence of CIN was decreased by 42% for using Vitamin C. Conclusion: Vitamins can reduce 46% incidence of CIN and Vitamin C may reduce 42% incidence of CIN in patients after CAG.
