Relationship Between Soluble ST2, Galectin-3 and Clinical Prognosis of Ventricular Septal Myectomy in Patients With Obstructive Hypertrophic Cardiomyopathy
10.3969/j.issn.1000-3614.2018.02.014
- VernacularTitle:可溶性ST2和半乳糖凝集素-3水平与室间隔心肌切除术后肥厚型梗阻性心肌病患者预后的相关性分析
- Author:
Jie LU
1
;
Xiao-Hong HUANG
;
Xi WU
;
Hao CUI
;
Jing-Jin WANG
;
Ming-Hu XIAO
;
Ying GUO
;
Chang-Peng SONG
;
Xin-Xin ZHENG
;
Xiao-Nan FANG
;
Shui-Yun WANG
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 特需医疗中心
- Keywords:
Receptors;
interleukin-1;
Galectin-3;
Cardiomyopathy;
hypertrophic
- From:
Chinese Circulation Journal
2018;33(2):166-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between plasma levels of soluble ST2 (sST2), galectin-3 (Gal-3) and clinical prognosis of ventricular septal myectomy in patients with obstructive hypertrophic cardiomyopathy (HOCM). Methods: A total of 200 consecutive HOCM patients received modified Morrow surgery in our hospital from 2011-03 to 2016-02 were studied. According to plasma levels of sST2, patients were divided into 3 groups: Low sST2 group (sST2<9.05 ng/ml), Middle sST2 group (sST2 9.05-16.74 ng/ml) and High sST2 group (sST2>16.74 ng/ml); based on plasma levels of Gal-3, patients were divided into another 3 groups: Low Gal-3 group (Gal-3<6.19 ng/ml), Middle group (Gal-3 6.19-8.22 ng/ml) and High Gal-3 group (Gal-3>8.22 ng/ml); in addition, Control group, n=42 volunteers without heart disease. Plasma levels of sST2 and Gal-3 were measured by ELISA, compared between Control group and HOCM group (n=42 patients with matched gender and age to Control group). The predictive value of sST2 and Gal-3 on major endpoint events including all cause death or cardiovascular hospitalization were assessed by Cox regression analysis.Results: Compared with Control group, plasma levels of sST2 and Gal-3 were increased in HOCM patients, P<0.01. The patients were followed-up for the average of 26 months, Kaplan-meier survival analysis showed that the incidences of composite endpoint event were similar at different levels of sST2 and Gal-3 (log-rank P=0.06 and P=0.68). Cox regression analysis indicated that either sST2 or Gal-3 could not independently predict the endpoint events, both P>0.05, while age was an independent risk factor for composite endpoint event occurrence (HR=1.06, 95% CI 1.02-1.11, P<0.01). Conclusion: Plasma levels of sST2 and Gal-3 were not related to clinical prognosis of ventricular septal myectomy in HOCM patients even they had increased sST2 and Gal-3; while advanced age was the independent predictor for endpoint event occurrence.
