Functional Changes of High Density Lipoprotein Subclass in Patients With Aortic Dissection
10.3969/j.issn.1000-3614.2018.01.018
- VernacularTitle:主动脉夹层患者高密度脂蛋白亚类功能变化研究
- Author:
Zhen-Kun WANG
1
;
Peng LI
;
Bing-Rong NIE
;
Chen LIU
;
Jing HE
Author Information
1. 珠海市第二人民医院 心血管内科
- Keywords:
Aortic aneurysm;
Lipoproteins,HDL
- From:
Chinese Circulation Journal
2018;33(1):92-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the functional changes of high density lipoprotein (HDL) subclass in patients with aortic dissection and to explore its clinical significance. Methods: Our research included in 2 groups: Aortic dissection group, n=60 patients and Control group, n=60 healthy subjects from regular physical examination. Blood levels of lipids, HDL subclass of HDL2 and HDL3, macrophage [3H] cholesterol efflux rate, intercellular adhesion molecule-1(ICAM-1), intravascular cellular adhesion molecule-1 (IVCAM-1) and paraoxonase 1 (PON-1) activity were examined and compared between 2 groups. Results: Compared with Control group, Aortic dissection group had reduced HDL2 level (41.15±19.02) mmol/L vs (60.48±22.19) mmol/L, P=0.010 and elevated HDL3 level (58.85±29.97) mmol/L vs (39.52±30.15) mmol/L, P=0.013;decreased macrophage [3H] cholesterol efflux rate (5.79±0.97) ％ vs (11.45±2.15) ％, P<0.01 and decreased PON-l activity (125.62±9.90) μ/ml vs (158.72±13.27) μ/ml, P<0.01; increased expressions of ICAM-1 (33571.85±2529.97) vs (17239.52±4330.15) and IVCAM-1 (442.15±119.02) vs (260.48±92.19) by fluorescence intensity, both P<0.05. Conclusion: Aortic dissection patients showed damaged HDL subclass reverse cholesterol transportation function and anti-oxidative function, both of them were lower than healthy population.
