Imbalance in matrix metalloproteinases and matrix metalloproteinase inhibitors from diseased splenic vein and varicose great saphenous vein under high hemodynamics
10.3969/j.issn.1009-9905.2018.02.003
- VernacularTitle:高流体静力压下脾静脉和大隐静脉基质金属蛋白酶及抑制物失调研究
- Author:
Kun LI
1
;
Hong LI
;
Yuan LI
;
Yong-Bo XU
;
Hai-Bo CHU
;
Hao-Fu WANG
Author Information
1. 青岛大学 研究生院
- Keywords:
Varicose Vein;
Diseased splenic vein;
Matrix metalloproteinases;
Matrix metalloproteinase inhibitors
- From:
Chinese Journal of Current Advances in General Surgery
2018;21(2):90-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the differences in matrix metalloproteinases (MMPs) and matrix metalloproteinase inhibitors (TIMPs) from diseased splenic vein (DSVs) and varicose great saphenous vein (VGSVs) under high hemodynamics.Methods:Seventy-two specimens of DSVs,normal splenic veins (SVs),VGSVs,and normal great saphenous vein (GSVs) were collected.Venous wall in the four groups,MMP-2,MMP-9,TIMP-1,and TIMP-2 protein expression were observed and MMP-2,MMP-9,TIMP-1,TIMP-2 proteins positive expression ratio and mRNA expression were determined.Results:DSVs and VGSVs in the two groups,MMP-2,MMP-9,TIMP-1,TIMP-2 proteins with clustered strong expression were observed;In DSVs group,MMP-2,MMP-9,TIMP-1,TIMP-2 protein positive expression ratio and mRNA expression were significantly increased compared with SVs group,while in VGSVs group,MMP-2,MMP-9,TIMP-1,TIMP-2 protein positive expression ratio and mRNA expression were significantly increased compared with GSVs group (P＜0.05).VGSVs/GSVs ratio was significantly increased compared with DSVs/SVs ratio (P＜0.05).Conclusion:Under high hemodynamics,the dysequilibrium of MMPs and TIMPs from splenic vein and great saphenous vein,These results may be one of the molecular mechanism in vascular remodeling.
