Relationship between serum fibulin-3 level and clinicopathological factors in patients with colon cancer
10.3969/j.issn.1009-9905.2017.10.004
- VernacularTitle:结肠癌患者Fibulin-3水平与临床病理关系
- Author:
Lei ZHU
1
;
Liang XU
;
Chun-Lu MU
;
Wei SUN
;
Jie WU
Author Information
1. 辽河油田总医院普外科 辽宁盘锦124010
- Keywords:
Fibulin-3;
Colon cancer
- From:
Chinese Journal of Current Advances in General Surgery
2017;20(10):767-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to assess serum fibulin-3 levels in patients with colon cancer compared with healthy controls and its relationship to demographics and tumor pathology.Methods:A total of 97 patients (mean age,59.6 years;57.7％ males) with colon cancer and 86 controls (mean age,58.8 years;54.7％ males) were included.Serum levels of fibulin-3 were determined using a commercially available sandwich ELISA (Enzyme-Linked ImmunoSorbent Assay).Results:Preoperative serum fibulin-3 levels were significantly lower in the group of patients with colon cancer(39.86 ± 24.37) ng/mL compared with the control group (94.25 ± 31.28) ng/mL.Preoperative fibulin-3 levels and negatively correlated with the degree of tumor TNM stage (P＜0.05),fibulin-3 levels gradually decreased by tumor stage from Ⅰ to Ⅳ and the difference is statistically significant.The serum fibulin-3 levels were correlated significantly with tumor size,lymph node metastasis,distant metastasis and CEA levels(P＜0.05).Conclusion:It was concluded that fibulin-3 is expressed at a lower level in colon cancer,and it is significant correlated with tumor burden,decreased level of fibulin-3 can serve as a marker for advanced colon cancer.
