Progress on nuclear factor-E2 related factor 2 transcription factors in sepsis

VernacularTitle:Nrf2转录因子在脓毒症中的研究进展
Author: Xingyu WANG ¹ ; Tao CHEN ; Xiaoyuan MA ; Wenjuan HUANG ; Qi HUANG ; Kuan LIU ; Huaping LIANG
Author Information

1. 遵义医学院附属医院重症医学科
Keywords: Nuclear factor-E2-related factor 2; Sepsis; Antioxidant stress
From: Chinese Critical Care Medicine 2018;30(8):810-814
CountryChina
Language:Chinese
Abstract: Sepsis is a critical complication of severe trauma, large area burns, infection, and major surgery etc., which can induce septic shock and multiple organ dysfunction syndrome (MODS), and its incidence and mortality are always high. Nuclear factor-E2 related factor 2 (Nrf 2) is an important transcription factor of antioxidant stress response. It plays a key role in the treatment of sepsis by regulating the expression of antioxidant enzyme and phase Ⅱ detoxification enzyme mediated by antioxidant response element (ARE). In this article we review the changes, related regulation mechanism and reversing measures of Nrf 2 in sepsis, aiming to provide a reference for the effective intervention measures of sepsis.