Pathogenesis of sepsis-induced myocardial dysfunction

VernacularTitle:脓毒症相关心肌功能障碍的发病机制
Author: Yunpeng LOU ^{1
,

2} ; Zhaofen LIN
Author Information

1. 200003 上海,第二军医大学长征医院急救科
2. 266071 山东青岛,解放军第401医院重症医学科
Keywords: Sepsis; Myocardial dysfunction; Pathogenesis
From: Chinese Critical Care Medicine 2018;30(4):374-376
CountryChina
Language:Chinese
Abstract: Sepsis is a common disease in intensive care units (ICU), and the resulted multi-organ dysfunction syndrome (MODS) is the main cause of death in patients with severe sepsis. The cardiovascular system is one of the most important target organ for sepsis. The severity of cardiac dysfunction is closely related to the clinical prognosis of patients with sepsis. Studies have reported that various cytokines are expressed during sepsis. They have influence on myocardial contractile function, mitochondrial function and self-regulation. Where after, it will induce cardiomyocyte apoptosis, which can lead to myocardial dysfunction. In this article, the pathogenesis of sepsis-induced myocardial dysfunction (SIMD) were reviewed to further clarify the pathogenesis of SIMD, and provide theoretical basis for subsequent research.