Risk factors for gestational diabetes mellitus in advanced maternal age at the early stage of pregnancy
10.3969/j.issn.1006-6187.2018.06.004
- VernacularTitle:高龄孕产妇孕早期妊娠糖尿病的危险因素分析
- Author:
Xiaomei WANG
1
;
Xiaoling WANG
;
Shuna BU
Author Information
1. 100026,首都医科大学附属北京妇产医院产科
- Keywords:
Advanced maternal age;
Early stage of pregnancy;
Diabetes mellitus,gestational;
Risk factors
- From:
Chinese Journal of Diabetes
2018;26(6):455-458
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors for gestational diabetes mellitus (GDM ) in advanced maternal age (AMA) at the early stage of pregnancy .Methods A total of 1200 subjects with AMA were enrolled in this study as AMA group from Jun 2016 to Jul 2017 in Beijing Obstetrics and Gynecology Hospital of Capital Medical University .Each group was further divided according to OGTT results :GDM group and NGDM group .The risk factors of GDM were analyzed .Results The prevalence of GDM was 24.17%(290/1200) .The history of type 2 diabetes in first-degree relatives,pre-pregnancy BMI,TG,FPG,FIns,and HOMA-IR were significantly different in the two groups (P＜0.05) .Pearson correlation analysis showed that GDM was positively correlated with the history of type 2 diabetes in first-degree relatives,pre-pregnancy BMI,TG,FPG,FIns and HOMA-IR (r= 0.519,0.413,0.451, 0.625,0.531,0.214,P＜ 0.05) .Multivariate logistic regression analysis showed that history of type 2 diabetes in first-degree relatives,pre-pregnancy BMI,TG,FPG,FIns and HOMA-IR were independent risk factors for GDM (OR=1.635,1.133,2.153,2.418,1.390,1.901,P＜0.05) .Conclusion During early pregnancy in subjects with AMA,TG,FPG,FIns,history of type 2 diabetes in first-degree relatives,pre-pregnancy BMI were independent risk factors for GDM .
