Association between serum Angptl 2 and carotid atherosclerosis in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2018.04.008
- VernacularTitle:2型糖尿病患者血清血管生成素样蛋白2的影响因素及其与颈动脉粥样硬化相关性的观察
- Author:
Xiaoran DONG
1
;
Hong XU
;
Xingbo CHENG
Author Information
1. 215006,苏州大学附属第一医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Angiopoietin-like protein 2;
Carotid atherosclerosis
- From:
Chinese Journal of Diabetes
2018;26(4):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence factors of serum Angptl 2 levels is to explore the relationship between serum Angptl 2 and carotid atherosclerosis (CAS) in patients with type 2 diabetes mellitus (T2DM). Methods 114 cases of T2DM in clinic were selected.According to the results of color doppler ultrasonography,the patients were divided into T2DM with CAS group(T2DM + CAS,n=58)and simple T2DM group(n= 56).56 healthy subjects were selected as normal control (NC)group during the same period.ELISA method was used to detect the level of serum Angptl 2. Results Serum Angptl 2 levels were significantly higher in T2DM + CAS group and T2DM group than in NC group [(69.83 ± 12.07) vs (42.93 ± 10.44)vs (24.26 ± 8.78)ng/ml,P< 0.01].Correlation analysis showed that serum Angptl 2 was positively correlated with age,BMI,SBP,DBP,TC,TG,LDL-C,FPG and HbA1c in T2DM patients (r=0.574,0.325,0.528,0.308,0.396,0.387,0.295,0.536 and 0.601,respectively,P<0.01),and negatively correlated with HDL-C and FIns in T2DM patients (r= -0.248,-0.352,P<0.01).Similarly,multiple regression analysis showed that FIns,and HbA1c were the independent factors of serum Angptl 2 (β= -2.186,2.680,P<0.01). Conclusion Serum Angptl 2 level is closely related to obesity,blood pressure,blood glucose,blood lipid and insulin.Serum Angptl 2 may play an important role in the development of T2DM and carotid atherosclerosis.
